Mitochondrial dysfunction induced by frataxin deficiency is associated with cellular senescence and abnormal calcium metabolism

Friedreich ataxia is considered a neurodegenerative disorder involving both the peripheral and central nervous systems. Dorsal root ganglia (DRG) are the major target tissue structures. This neuropathy is caused by mutations in the FXN gene that encodes frataxin. Here, we investigated the mitochondr...

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Detaylı Bibliyografya
Asıl Yazarlar: Bolinches-Amorós, Arantxa, Mollá, Belén, Pla-Martín, David, Palau, Francesc, González-Cabo, Pilar
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2014
Konular:
Neuroscience
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026758/
https://ncbi.nlm.nih.gov/pubmed/24860428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00124
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