Mitochondrial dysfunction induced by frataxin deficiency is associated with cellular senescence and abnormal calcium metabolism

Friedreich ataxia is considered a neurodegenerative disorder involving both the peripheral and central nervous systems. Dorsal root ganglia (DRG) are the major target tissue structures. This neuropathy is caused by mutations in the FXN gene that encodes frataxin. Here, we investigated the mitochondr...

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Main Authors: Bolinches-Amorós, Arantxa, Mollá, Belén, Pla-Martín, David, Palau, Francesc, González-Cabo, Pilar
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2014
主題:
Neuroscience
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026758/
https://ncbi.nlm.nih.gov/pubmed/24860428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00124
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