Mitochondrial dysfunction induced by frataxin deficiency is associated with cellular senescence and abnormal calcium metabolism

Friedreich ataxia is considered a neurodegenerative disorder involving both the peripheral and central nervous systems. Dorsal root ganglia (DRG) are the major target tissue structures. This neuropathy is caused by mutations in the FXN gene that encodes frataxin. Here, we investigated the mitochondr...

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Библиографические подробности
Главные авторы: Bolinches-Amorós, Arantxa, Mollá, Belén, Pla-Martín, David, Palau, Francesc, González-Cabo, Pilar
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2014
Предметы:
Neuroscience
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026758/
https://ncbi.nlm.nih.gov/pubmed/24860428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00124
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