Two different pathogenic mechanisms, dying-back axonal neuropathy and pancreatic senescence, are present in the YG8R mouse model of Friedreich’s ataxia

Frataxin (FXN) deficiency causes Friedreich’s ataxia (FRDA), a multisystem disorder with neurological and non-neurological symptoms. FRDA pathophysiology combines developmental and degenerative processes of dorsal root ganglia (DRG), sensory nerves, dorsal columns and other central nervous structure...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Dis Model Mech
Main Authors: Mollá, Belén, Riveiro, Fátima, Bolinches-Amorós, Arantxa, Muñoz-Lasso, Diana C., Palau, Francesc, González-Cabo, Pilar
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4920149/
https://ncbi.nlm.nih.gov/pubmed/27079523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.024273
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