Phosphodiesterase Inhibitors Revert Axonal Dystrophy in Friedreich’s Ataxia Mouse Model

Friedreich’s ataxia (FRDA) is a neurodegenerative disorder caused by an unstable GAA repeat expansion within intron 1 of the FXN gene and characterized by peripheral neuropathy. A major feature of FRDA is frataxin deficiency with the loss of large sensory neurons of the dorsal root ganglia (DRG), na...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neurotherapeutics
Prif Awduron: Mollá, Belén, Muñoz-Lasso, Diana C., Calap, Pablo, Fernandez-Vilata, Angel, de la Iglesia-Vaya, María, Pallardó, Federico V., Moltó, Maria Dolores, Palau, Francesc, Gonzalez-Cabo, Pilar
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer International Publishing 2019
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554462/
https://ncbi.nlm.nih.gov/pubmed/30761510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-018-00706-z
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