Mitochondrial dysfunction induced by frataxin deficiency is associated with cellular senescence and abnormal calcium metabolism

Friedreich ataxia is considered a neurodegenerative disorder involving both the peripheral and central nervous systems. Dorsal root ganglia (DRG) are the major target tissue structures. This neuropathy is caused by mutations in the FXN gene that encodes frataxin. Here, we investigated the mitochondr...

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Autori principali: Bolinches-Amorós, Arantxa, Mollá, Belén, Pla-Martín, David, Palau, Francesc, González-Cabo, Pilar
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2014
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026758/
https://ncbi.nlm.nih.gov/pubmed/24860428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00124
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