Nanometer-scale siRNA carriers incorporating peptidomimetic oligomers: physical characterization and biological activity

Synthetic short interfering RNA (siRNA) oligonucleotides can trigger the RNA interference pathway and lead to selective gene silencing. Despite considerable enthusiasm and investment, formidable challenges remain that may deter translating this breakthrough discovery into clinical applications. In p...

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Autori principali: Konca, Yeliz Utku, Kirshenbaum, Kent, Zuckermann, Ronald N
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2014
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026564/
https://ncbi.nlm.nih.gov/pubmed/24872690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S57449
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