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Molecular Mechanisms of Action and Therapeutic Uses of Pharmacological Inhibitors of HIF–Prolyl 4-Hydroxylases for Treatment of Ischemic Diseases

Significance: In this review, we have discussed the efficacy and effect of small molecules that act as prolyl hydroxylase domain inhibitors (PHDIs). The use of these compounds causes upregulation of the pro-angiogenic factors and hypoxia inducible factor-1α and -2α (HIF-1α and HIF-2α) to enhance ang...

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Main Authors: Selvaraju, Vaithinathan, Parinandi, Narasimham L., Adluri, Ram Sudheer, Goldman, Joshua W., Hussain, Naveed, Sanchez, Juan A., Maulik, Nilanjana
格式: Artigo
語言:Inglês
出版: Mary Ann Liebert, Inc. 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026215/
https://ncbi.nlm.nih.gov/pubmed/23992027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2013.5186
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