Disruption of Hypoxia-Inducible Transcription Factor-Prolyl Hydroxylase Domain-1 (PHD-1(−/−)) Attenuates Ex Vivo Myocardial Ischemia/Reperfusion Injury Through Hypoxia-Inducible Factor-1α Transcription Factor and Its Target Genes in Mice

Hypoxia-inducible transcription factor (HIF)-prolyl hydroxylases domain (PHD-1–3) are oxygen sensors that regulate the stability of the HIFs in an oxygen-dependent manner. Suppression of PHD enzymes leads to stabilization of HIFs and offers a potential treatment option for many ischemic disorders, s...

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Autors principals: Adluri, Ram Sudheer, Thirunavukkarasu, Mahesh, Dunna, Nageswara Rao, Zhan, Lijun, Oriowo, Babatunde, Takeda, Kotaro, Sanchez, Juan A., Otani, Hajime, Maulik, Gautam, Fong, Guo-Hua, Maulik, Nilanjana
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2011
Matèries:
Forum Original Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159109/
https://ncbi.nlm.nih.gov/pubmed/21083501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2010.3769
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