Small molecule agonists of integrin CD11b/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury

BACKGROUND: CD11b/CD18 is a key adhesion receptor that mediates leukocyte adhesion, migration and immune functions. We recently identified novel compounds, leukadherins, that allosterically enhance CD11b/CD18-dependent cell adhesion and reduce inflammation in vivo, suggesting integrin activation to...

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Detalhes bibliográficos
Main Authors: Faridi, Mohd Hafeez, Altintas, Mehmet M., Gomez, Camilo, Duque, Juan Camilo, Vazquez-Padron, Roberto I., Gupta, Vineet
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026195/
https://ncbi.nlm.nih.gov/pubmed/23454649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2013.02.018
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