Small Molecule–Mediated Activation of the Integrin CD11b/CD18 Reduces Inflammatory Disease

The integrin CD11b/CD18 (also known as Mac-1), which is a heterodimer of the α(M) (CD11b) and β(2) (CD18) subunits, is critical for leukocyte adhesion and migration and for immune functions. Blocking integrin-mediated leukocyte adhesion, although beneficial in experimental models, has had limited su...

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Publicado no:Sci Signal
Main Authors: Maiguel, Dony, Faridi, Mohd Hafeez, Wei, Changli, Kuwano, Yoshihiro, Balla, Keir M., Hernandez, Dayami, Barth, Constantinos J., Lugo, Geanncarlo, Donnelly, Mary, Nayer, Ali, Moita, Luis F., Schürer, Stephan, Traver, David, Ruiz, Phillip, Vazquez-Padron, Roberto I., Ley, Klaus, Reiser, Jochen, Gupta, Vineet
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507414/
https://ncbi.nlm.nih.gov/pubmed/21900205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001811
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