High-Throughput Screening based Identification of Small Molecule Antagonists of Integrin CD11b/CD18 Ligand Binding

Binding of leukocyte specific integrin CD11b/CD18 to its physiologic ligands is important for the development of normal immune response in vivo. Integrin CD11b/CD18 is also a key cellular effector of various inflammatory and autoimmune diseases. However, small molecules selectively inhibiting the fu...

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Hlavní autoři: Faridi, Mohd Hafeez, Maiguel, Dony, Brown, Brock T., Suyama, Eigo, Barth, Constantinos J., Hedrick, Michael, Vasile, Stefan, Sergienko, Eduard, Schürer, Stephan, Gupta, Vineet
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065194/
https://ncbi.nlm.nih.gov/pubmed/20188705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.02.151
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