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Agonist Leukadherin-1 Increases CD11b/CD18-Dependent Adhesion Via Membrane Tethers

Integrin CD11b/CD18 is a key adhesion receptor that mediates leukocyte migration and immune functions. Leukadherin-1 (LA1) is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1. Here, we used single-molecule force spectroscopy to investigate the biophysica...

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Detalhes bibliográficos
Main Authors: Celik, Emrah, Faridi, Mohd. Hafeez, Kumar, Vinay, Deep, Shashank, Moy, Vincent T., Gupta, Vineet
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853324/
https://ncbi.nlm.nih.gov/pubmed/24314082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.10.020
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