Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened

[Image: see text] Inhibitors of the Hedgehog signaling pathway have generated a great deal of interest in the oncology area due to the mounting evidence of their potential to provide promising therapeutic options for patients. Herein, we describe the discovery strategy to overcome the issues inheren...

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Detalhes bibliográficos
Main Authors: Munchhof, Michael J., Li, Qifang, Shavnya, Andrei, Borzillo, Gary V., Boyden, Tracey L., Jones, Christopher S., LaGreca, Susan D., Martinez-Alsina, Luis, Patel, Nandini, Pelletier, Kathleen, Reiter, Larry A., Robbins, Michael D., Tkalcevic, George T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025788/
https://ncbi.nlm.nih.gov/pubmed/24900436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml2002423
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