Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened

[Image: see text] Inhibitors of the Hedgehog signaling pathway have generated a great deal of interest in the oncology area due to the mounting evidence of their potential to provide promising therapeutic options for patients. Herein, we describe the discovery strategy to overcome the issues inheren...

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Hauptverfasser: Munchhof, Michael J., Li, Qifang, Shavnya, Andrei, Borzillo, Gary V., Boyden, Tracey L., Jones, Christopher S., LaGreca, Susan D., Martinez-Alsina, Luis, Patel, Nandini, Pelletier, Kathleen, Reiter, Larry A., Robbins, Michael D., Tkalcevic, George T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2011
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025788/
https://ncbi.nlm.nih.gov/pubmed/24900436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml2002423
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