Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1

[Image: see text] Acyl-CoA:diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final committed step in the biosynthesis of triglycerides. DGAT-1 knockout mice have been shown to be resistant to diet-induced obesity and have increased insulin sensitivity. Thus, inhibition of DGAT-1 may represent...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Dow, Robert L., Li, Jian-Cheng, Pence, Michael P., Gibbs, E. Michael, LaPerle, Jennifer L., Litchfield, John, Piotrowski, David W., Munchhof, Michael J., Manion, Tara B., Zavadoski, William J., Walker, Gregory S., McPherson, R. Kirk, Tapley, Susan, Sugarman, Eliot, Guzman-Perez, Angel, DaSilva-Jardine, Paul
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2011
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018057/
https://ncbi.nlm.nih.gov/pubmed/24900321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200051p
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