Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1

[Image: see text] Acyl-CoA:diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final committed step in the biosynthesis of triglycerides. DGAT-1 knockout mice have been shown to be resistant to diet-induced obesity and have increased insulin sensitivity. Thus, inhibition of DGAT-1 may represent...

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Bibliographic Details
Main Authors: Dow, Robert L., Li, Jian-Cheng, Pence, Michael P., Gibbs, E. Michael, LaPerle, Jennifer L., Litchfield, John, Piotrowski, David W., Munchhof, Michael J., Manion, Tara B., Zavadoski, William J., Walker, Gregory S., McPherson, R. Kirk, Tapley, Susan, Sugarman, Eliot, Guzman-Perez, Angel, DaSilva-Jardine, Paul
Format: Artigo
Language:Inglês
Published: American Chemical Society 2011
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018057/
https://ncbi.nlm.nih.gov/pubmed/24900321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200051p
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