Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1

[Image: see text] Acyl-CoA:diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final committed step in the biosynthesis of triglycerides. DGAT-1 knockout mice have been shown to be resistant to diet-induced obesity and have increased insulin sensitivity. Thus, inhibition of DGAT-1 may represent...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Dow, Robert L., Li, Jian-Cheng, Pence, Michael P., Gibbs, E. Michael, LaPerle, Jennifer L., Litchfield, John, Piotrowski, David W., Munchhof, Michael J., Manion, Tara B., Zavadoski, William J., Walker, Gregory S., McPherson, R. Kirk, Tapley, Susan, Sugarman, Eliot, Guzman-Perez, Angel, DaSilva-Jardine, Paul
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2011
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018057/
https://ncbi.nlm.nih.gov/pubmed/24900321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200051p
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires