Synthesis and Functionalization of Cyclic Sulfonimidamides: A Novel Chiral Heterocyclic Carboxylic Acid Bioisostere

[Image: see text] An efficient synthesis of aryl substituted cyclic sulfonimidamides designed as chiral nonplanar heterocyclic carboxylic acid bioisosteres is described. The cyclic sulfonimidamide ring system could be prepared in two steps from a trifluoroacetyl protected sulfinamide and methyl este...

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Autors principals: Pemberton, Nils, Graden, Henrik, Evertsson, Emma, Bratt, Emma, Lepistö, Matti, Johannesson, Petra, Svensson, Per H.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2012
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025735/
https://ncbi.nlm.nih.gov/pubmed/24900513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3000935
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