Saccharin Aza Bioisosteres—Synthesis and Preclinical Property Comparisons

[Image: see text] Saccharin is a well-known scaffold in drug discovery. Herein, we report the synthesis and preclinical property comparisons of three bioisosteres of saccharin: aza-pseudosaccharins (cluster B), and two new types of aza-saccharins (clusters C and D). We demonstrate a convenient proto...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:ACS Med Chem Lett
Autors principals: Chen, Yantao, Aurell, Carl-Johan, Pettersen, Anna, Lewis, Richard J., Hayes, Martin A., Lepistö, Matti, Jonson, Anna C., Leek, Hanna, Thunberg, Linda
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2017
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467200/
https://ncbi.nlm.nih.gov/pubmed/28626531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00137
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars