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Saccharin Aza Bioisosteres—Synthesis and Preclinical Property Comparisons
[Image: see text] Saccharin is a well-known scaffold in drug discovery. Herein, we report the synthesis and preclinical property comparisons of three bioisosteres of saccharin: aza-pseudosaccharins (cluster B), and two new types of aza-saccharins (clusters C and D). We demonstrate a convenient proto...
Gardado en:
| Publicado en: | ACS Med Chem Lett |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Chemical
Society
2017
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5467200/ https://ncbi.nlm.nih.gov/pubmed/28626531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00137 |
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