CCR5/CD4/CXCR4 oligomerization prevents HIV-1 gp120(IIIB) binding to the cell surface

CCR5 and CXCR4, the respective cell surface coreceptors of R5 and X4 HIV-1 strains, both form heterodimers with CD4, the principal HIV-1 receptor. Using several resonance energy transfer techniques, we determined that CD4, CXCR4, and CCR5 formed heterotrimers, and that CCR5 coexpression altered the...

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Hauptverfasser: Martínez-Muñoz, Laura, Barroso, Rubén, Dyrhaug, Sunniva Y., Navarro, Gemma, Lucas, Pilar, Soriano, Silvia F., Vega, Beatriz, Costas, Coloma, Muñoz-Fernández, M. Ángeles, Santiago, César, Frade, José Miguel Rodríguez, Franco, Rafael, Mellado, Mario
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4024905/
https://ncbi.nlm.nih.gov/pubmed/24778234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322887111
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