Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the Protean Effects of “Selective” Antagonists

Chemokine receptors constitute an attractive family of drug targets in the frame of inflammatory diseases. However, targeting specific chemokine receptors may be complicated by their ability to form dimers or higher order oligomers. Using a combination of luminescence complementation and bioluminesc...

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Detalhes bibliográficos
Main Authors: Sohy, Denis, Yano, Hideaki, de Nadai, Patricia, Urizar, Eneko, Guillabert, Aude, Javitch, Jonathan A., Parmentier, Marc, Springael, Jean-Yves
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781525/
https://ncbi.nlm.nih.gov/pubmed/19758998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.054809
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