Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the Protean Effects of “Selective” Antagonists

Chemokine receptors constitute an attractive family of drug targets in the frame of inflammatory diseases. However, targeting specific chemokine receptors may be complicated by their ability to form dimers or higher order oligomers. Using a combination of luminescence complementation and bioluminesc...

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Main Authors: Sohy, Denis, Yano, Hideaki, de Nadai, Patricia, Urizar, Eneko, Guillabert, Aude, Javitch, Jonathan A., Parmentier, Marc, Springael, Jean-Yves
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Mechanisms of Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781525/
https://ncbi.nlm.nih.gov/pubmed/19758998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.054809
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