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Continuous Covariate Imbalance and Conditional Power for Clinical Trial Interim Analyses

Oftentimes valid statistical analyses for clinical trials involve adjustment for known influential covariates, regardless of imbalance observed in these covariates at baseline across treatment groups. Thus, it must be the case that valid interim analyses also properly adjust for these covariates. Th...

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Main Authors: Ciolino, Jody D., Martin, Renee' H., Zhao, Wenle, Jauch, Edward C., Hill, Michael D., Palesch, Yuko Y.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4024327/
https://ncbi.nlm.nih.gov/pubmed/24607294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cct.2014.02.007
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