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Minimal sufficient balance—a new strategy to balance baseline covariates and preserve randomness of treatment allocation

In many clinical trials, baseline covariates could affect the primary outcome. Commonly used strategies to balance baseline covariates include stratified constrained randomization and minimization. Stratification is limited to few categorical covariates. Minimization lacks the randomness of treatmen...

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Detalhes bibliográficos
Main Authors: Zhao, Wenle, Hill, Michael D, Palesch, Yuko
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474894/
https://ncbi.nlm.nih.gov/pubmed/22287602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0962280212436447
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