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Statistical properties of minimal sufficient balance and minimization as methods for controlling baseline covariate imbalance at the design stage of sequential clinical trials

When the number of baseline covariates whose imbalance needs to be controlled in a sequential randomized controlled trial is large, minimization is the most commonly used method for randomizing treatment assignments. The lack of allocation randomness associated with the minimization method has been...

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Bibliographic Details
Published in:Stat Med
Main Authors: Lauzon, Steven D., Ramakrishnan, Viswanathan, Nietert, Paul J., Ciolino, Jody D., Hill, Michael D., Zhao, Wenle
Format: Artigo
Language:Inglês
Published: 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7462097/
https://ncbi.nlm.nih.gov/pubmed/32363614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.8552
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