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Total Synthesis of (±)-Bisabosqual A
The synthesis of the novel squalene synthase inhibitor, bisabosqual A, was completed in 14 steps (longest linear sequence) from commercially available starting materials. The doubly convergent route employs a tandem 5-exo, 6-exo radical cyclization as the key step. This reaction assembles the fully...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4024202/ https://ncbi.nlm.nih.gov/pubmed/23268693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3108577 |
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