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Total Synthesis of (±)-Bisabosqual A

The synthesis of the novel squalene synthase inhibitor, bisabosqual A, was completed in 14 steps (longest linear sequence) from commercially available starting materials. The doubly convergent route employs a tandem 5-exo, 6-exo radical cyclization as the key step. This reaction assembles the fully...

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Detalhes bibliográficos
Main Authors: am Ende, Christopher W., Zhou, Zhou, Parker, Kathlyn A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4024202/
https://ncbi.nlm.nih.gov/pubmed/23268693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3108577
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