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Total synthesis of the potent androgen receptor antagonist, (−)-arabilin. A strategic, biomimetic [1,7]-hydrogen shift
The first total synthesis of (−)-arabilin, a Streptomyces metabolite that inhibits hormone activation of the androgen receptor (AR), was completed. The key step, a [1,7]-hydrogen shift, establishes the enol ether-containing skipped tetraene substructure. This non-enzymatic, pericyclic reaction is co...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3320024/ https://ncbi.nlm.nih.gov/pubmed/22085260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja209459f |
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