Disuccinyl Betulin Triggers Metacaspase-Dependent Endonuclease G-Mediated Cell Death in Unicellular Protozoan Parasite Leishmania donovani

The unicellular organism Leishmania undergoes apoptosis-like cell death in response to external stress or exposure to antileishmanial agents. Here, we showed that 3-O,28-O-disuccinyl betulin (DiSB), a potent topoisomerase type IB inhibitor, induced parasitic cell death by generating oxidative stress...

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Autors principals: Chowdhury, Sayan, Mukherjee, Tulika, Chowdhury, Somenath Roy, Sengupta, Souvik, Mukhopadhyay, Sibabrata, Jaisankar, Parasuraman, Majumder, Hemanta K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023740/
https://ncbi.nlm.nih.gov/pubmed/24468787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02193-13
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