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TRPV1 structures in distinct conformations reveal mechanisms of activation

TRP channels are polymodal signal detectors that respond to a wide range of physical and chemical stimuli. Elucidating how these channels integrate and convert physiological signals into channel opening is essential to understanding how they regulate cell excitability under normal and pathophysiolog...

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Autores principales: Cao, Erhu, Liao, Maofu, Cheng, Yifan, Julius, David
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023639/
https://ncbi.nlm.nih.gov/pubmed/24305161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12823
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