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A distinct structural mechanism underlies TRPV1 activation by piperine
Piperine, the principle pungent compound in black peppers, is known to activate the capsaicin receptor TRPV1 ion channel. How piperine interacts with the channel protein, however, remains unclear. Here we show that piperine binds to the same ligand-binding pocket as capsaicin but in different poses....
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| Publié dans: | Biochem Biophys Res Commun |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6626684/ https://ncbi.nlm.nih.gov/pubmed/31213294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2019.06.039 |
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