Lead Exposure Disrupts Global DNA Methylation in Human Embryonic Stem Cells and Alters Their Neuronal Differentiation

Exposure to lead (Pb) during childhood can result in learning disabilities and behavioral problems. Although described in animal models, whether Pb exposure also alters neuronal differentiation in the developing brains of exposed children is unknown. Here, we investigated the effects of physiologica...

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Autors principals: Senut, Marie-Claude, Sen, Arko, Cingolani, Pablo, Shaik, Asra, Land, Susan J., Ruden, Douglas M.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
Matèries:
Neurotoxicology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023291/
https://ncbi.nlm.nih.gov/pubmed/24519525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu028
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