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Multigenerational epigenetic inheritance in humans: DNA methylation changes associated with maternal exposure to lead can be transmitted to the grandchildren

We report that the DNA methylation profile of a child’s neonatal whole blood can be significantly influenced by his or her mother’s neonatal blood lead levels (BLL). We recruited 35 mother-infant pairs in Detroit and measured the whole blood lead (Pb) levels and DNA methylation levels at over 450,00...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sen, Arko, Heredia, Nicole, Senut, Marie-Claude, Land, Susan, Hollocher, Kurt, Lu, Xiangyi, Dereski, Mary O., Ruden, Douglas M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586440/
https://ncbi.nlm.nih.gov/pubmed/26417717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14466
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