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Lead Exposure Disrupts Global DNA Methylation in Human Embryonic Stem Cells and Alters Their Neuronal Differentiation

Exposure to lead (Pb) during childhood can result in learning disabilities and behavioral problems. Although described in animal models, whether Pb exposure also alters neuronal differentiation in the developing brains of exposed children is unknown. Here, we investigated the effects of physiologica...

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Bibliografiske detaljer
Main Authors: Senut, Marie-Claude, Sen, Arko, Cingolani, Pablo, Shaik, Asra, Land, Susan J., Ruden, Douglas M.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023291/
https://ncbi.nlm.nih.gov/pubmed/24519525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu028
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