Lead exposure induces changes in 5-hydroxymethylcytosine clusters in CpG islands in human embryonic stem cells and umbilical cord blood

Prenatal exposure to neurotoxicants such as lead (Pb) may cause stable changes in the DNA methylation (5mC) profile of the fetal genome. However, few studies have examined its effect on the DNA de-methylation pathway, specifically the dynamic changes of the 5-hydroxymethylcytosine (5hmC) profile. Th...

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Veröffentlicht in:Epigenetics
Hauptverfasser: Sen, Arko, Cingolani, Pablo, Senut, Marie-Claude, Land, Susan, Mercado-Garcia, Adriana, Tellez-Rojo, Martha M, Baccarelli, Andrea A, Wright, Robert O, Ruden, Douglas M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623482/
https://ncbi.nlm.nih.gov/pubmed/26046694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2015.1050172
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