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Lead exposure induces changes in 5-hydroxymethylcytosine clusters in CpG islands in human embryonic stem cells and umbilical cord blood

Prenatal exposure to neurotoxicants such as lead (Pb) may cause stable changes in the DNA methylation (5mC) profile of the fetal genome. However, few studies have examined its effect on the DNA de-methylation pathway, specifically the dynamic changes of the 5-hydroxymethylcytosine (5hmC) profile. Th...

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Dades bibliogràfiques
Publicat a:Epigenetics
Autors principals: Sen, Arko, Cingolani, Pablo, Senut, Marie-Claude, Land, Susan, Mercado-Garcia, Adriana, Tellez-Rojo, Martha M, Baccarelli, Andrea A, Wright, Robert O, Ruden, Douglas M
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623482/
https://ncbi.nlm.nih.gov/pubmed/26046694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2015.1050172
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