Lead exposure induces changes in 5-hydroxymethylcytosine clusters in CpG islands in human embryonic stem cells and umbilical cord blood

Prenatal exposure to neurotoxicants such as lead (Pb) may cause stable changes in the DNA methylation (5mC) profile of the fetal genome. However, few studies have examined its effect on the DNA de-methylation pathway, specifically the dynamic changes of the 5-hydroxymethylcytosine (5hmC) profile. Th...

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Bibliografski detalji
Izdano u:Epigenetics
Glavni autori: Sen, Arko, Cingolani, Pablo, Senut, Marie-Claude, Land, Susan, Mercado-Garcia, Adriana, Tellez-Rojo, Martha M, Baccarelli, Andrea A, Wright, Robert O, Ruden, Douglas M
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2015
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623482/
https://ncbi.nlm.nih.gov/pubmed/26046694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2015.1050172
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