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The interplay of DNA methylation over time with Th2 pathway genetic variants on asthma risk and temporal asthma transition

BACKGROUND: Genetic effects on asthma of genes in the T-helper 2 (Th2) pathway may interact with epigenetic factors including DNA methylation. We hypothesized that interactions between genetic variants and methylation in genes in this pathway (IL4, IL4R, IL13, GATA3, and STAT6) influence asthma risk...

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書誌詳細
主要な著者: Zhang, Hongmei, Tong, Xin, Holloway, John W, Rezwan, Faisal I, Lockett, Gabrielle A, Patil, Veeresh, Ray, Meredith, Everson, Todd M, Soto-Ramírez, Nelís, Arshad, S Hasan, Ewart, Susan, Karmaus, Wilfried
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023182/
https://ncbi.nlm.nih.gov/pubmed/24735657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1868-7083-6-8
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