The interplay of DNA methylation over time with Th2 pathway genetic variants on asthma risk and temporal asthma transition

BACKGROUND: Genetic effects on asthma of genes in the T-helper 2 (Th2) pathway may interact with epigenetic factors including DNA methylation. We hypothesized that interactions between genetic variants and methylation in genes in this pathway (IL4, IL4R, IL13, GATA3, and STAT6) influence asthma risk...

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Hlavní autoři: Zhang, Hongmei, Tong, Xin, Holloway, John W, Rezwan, Faisal I, Lockett, Gabrielle A, Patil, Veeresh, Ray, Meredith, Everson, Todd M, Soto-Ramírez, Nelís, Arshad, S Hasan, Ewart, Susan, Karmaus, Wilfried
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023182/
https://ncbi.nlm.nih.gov/pubmed/24735657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1868-7083-6-8
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