Targeted delivery of CD40L promotes restricted activation of antigen-presenting cells and induction of cancer cell death

BACKGROUND: Stimulation of CD40 can augment anti-cancer T cell immune responses by triggering effective activation and maturation of antigen-presenting cells (APCs). Although CD40 agonists have clinical activity in humans, the associated systemic activation of the immune system triggers dose-limitin...

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Detalhes bibliográficos
Main Authors: Brunekreeft, Kim L, Strohm, Corinna, Gooden, Marloes J, Rybczynska, Anna A, Nijman, Hans W, Grigoleit, Götz U, Helfrich, Wijnand, Bremer, Edwin, Siegmund, Daniela, Wajant, Harald, de Bruyn, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022212/
https://ncbi.nlm.nih.gov/pubmed/24741998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-85
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