The Ever-Expanding Immunomodulatory Role of Calreticulin in Cancer Immunity

Por de Bruyn, Marco, Wiersma, Valerie R., Helfrich, Wijnand, Eggleton, Paul, Bremer, Edwin
Publicado no Front Oncol (2015)

Carbon monoxide-Releasing Molecule-2 (CORM-2) attenuates acute hepatic ischemia reperfusion injury in rats

Por Wei, Yunwei, Chen, Ping, de Bruyn, Marco, Zhang, Weihui, Bremer, Edwin, Helfrich, Wijnand
Publicado em 2010

A versatile pretargeting approach for tumour-selective delivery and activation of TNF superfamily members

Por He, Yuan, van Bommel, Peter E., Samplonius, Douwe F., Bremer, Edwin, Helfrich, Wijnand
Publicado no Sci Rep (2017)

Exceptionally Potent Anti-Tumor Bystander Activity of an scFv:sTRAIL Fusion Protein with Specificity for EGP2 Toward Target Antigen-Negative Tumor Cells

Por Bremer, Edwin, Samplonius, Douwe, Kroesen, Bart-Jan, van Genne, Linda, de Leij, Lou, Helfrich, Wijnand
Publicado em 2004

CSPG4: A Target for Selective Delivery of Human Cytolytic Fusion Proteins and TRAIL

Por Jordaan, Sandra, Chetty, Shivan, Mungra, Neelakshi, Koopmans, Iris, van Bommel, Peter E., Helfrich, Wijnand, Barth, Stefan
Publicado no Biomedicines (2017)

Programmed Death Ligand 1 (PD-L1)-targeted TRAIL combines PD-L1-mediated checkpoint inhibition with TRAIL-mediated apoptosis induction

Por Hendriks, Djoke, He, Yuan, Koopmans, Iris, Wiersma, Valerie R., van Ginkel, Robert J., Samplonius, Douwe F., Helfrich, Wijnand, Bremer, Edwin
Publicado no Oncoimmunology (2016)

Targeted delivery of a designed sTRAIL mutant results in superior apoptotic activity towards EGFR-positive tumor cells

Por Bremer, Edwin, de Bruyn, Marco, Samplonius, Douwe F., Bijma, Theo, ten Cate, Bram, de Leij, Lou F. M. H., Helfrich, Wijnand
Publicado em 2008

Melanoma-associated Chondroitin Sulfate Proteoglycan (MCSP)-targeted delivery of soluble TRAIL potently inhibits melanoma outgrowth in vitro and in vivo

Por de Bruyn, Marco, Rybczynska, Anna A, Wei, Yunwei, Schwenkert, Michael, Fey, Georg H, Dierckx, Rudi AJO, van Waarde, Aren, Helfrich, Wijnand, Bremer, Edwin
Publicado em 2010

Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects

Por Eggleton, Paul, Bremer, Edwin, Tarr, Joanna M, de Bruyn, Marco, Helfrich, Wijnand, Kendall, Alexandra, Haigh, Richard C, Viner, Nick J, Winyard, Paul G
Publicado em 2011

The Glycan-Binding Protein Galectin-9 Has Direct Apoptotic Activity toward Melanoma Cells

Por Wiersma, Valerie R, de Bruyn, Marco, van Ginkel, Robert J, Sigar, Emily, Hirashima, Mitsuomi, Niki, Toshiro, Nishi, Nozomu, Samplonius, Douwe F, Helfrich, Wijnand, Bremer, Edwin
Publicado em 2012

CD20(+) T cells have a predominantly Tc1 effector memory phenotype and are expanded in the ascites of patients with ovarian cancer

Por de Bruyn, Marco, Wiersma, Valerie R, Wouters, Maartje C A, Samplonius, Douwe F, Klip, Harry G, Helfrich, Wijnand, Nijman, Hans W, Eggleton, Paul, Bremer, Edwin
Publicado no Oncoimmunology (2015)

Targeted delivery of CD40L promotes restricted activation of antigen-presenting cells and induction of cancer cell death

Por Brunekreeft, Kim L, Strohm, Corinna, Gooden, Marloes J, Rybczynska, Anna A, Nijman, Hans W, Grigoleit, Götz U, Helfrich, Wijnand, Bremer, Edwin, Siegmund, Daniela, Wajant, Harald, de Bruyn, Marco
Publicado em 2014

Galectin-9 Activates and Expands Human T-Helper 1 Cells

Por Gooden, Marloes J. M., Wiersma, Valerie R., Samplonius, Douwe F., Gerssen, Jurjen, van Ginkel, Robert J., Nijman, Hans W., Hirashima, Mitsuomi, Niki, Toshiro, Eggleton, Paul, Helfrich, Wijnand, Bremer, Edwin
Publicado em 2013

C-type lectin-like molecule-1 (CLL1)-targeted TRAIL augments the tumoricidal activity of granulocytes and potentiates therapeutic antibody-dependent cell-mediated cytotoxicity

Por Wiersma, Valerie R, de Bruyn, Marco, Shi, Ce, Gooden, Marloes JM, Wouters, Maartje CA, Samplonius, Douwe F, Hendriks, Djoke, Nijman, Hans W, Wei, Yunwei, Zhou, Jin, Helfrich, Wijnand, Bremer, Edwin
Publicado no MAbs (2015)

CD20-selective inhibition of CD47-SIRPα “don't eat me” signaling with a bispecific antibody-derivative enhances the anticancer activity of daratumumab, alemtuzumab and obinutuzumab...

Por van Bommel, Peter E., He, Yuan, Schepel, Ilona, Hendriks, Mark A. J. M., Wiersma, Valerie R., van Ginkel, Robert J., van Meerten, Tom, Ammatuna, Emanuele, Huls, Gerwin, Samplonius, Douwe F., Helfrich, Wijnand, Bremer, Edwin
Publicado no Oncoimmunology (2017)

The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux

Por Wiersma, Valerie R, de Bruyn, Marco, Wei, Yunwei, van Ginkel, Robert J, Hirashima, Mitsuomi, Niki, Toshiro, Nishi, Nozomu, Zhou, Jin, Pouwels, Simon D, Samplonius, Douwe F, Nijman, Hans W, Eggleton, Paul, Helfrich, Wijnand, Bremer, Edwin
Publicado no Autophagy (2015)

CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy

Por Komdeur, Fenne L., Wouters, Maartje C.A., Workel, Hagma H., Tijans, Aline M., Terwindt, Anouk L.J., Brunekreeft, Kim L., Plat, Annechien, Klip, Harry G., Eggink, Florine A., Leffers, Ninke, Helfrich, Wijnand, Samplonius, Douwe F., Bremer, Edwin, Wisman, G. Bea A., Daemen, Toos, Duiker, Evelien W., Hollema, Harry, Nijman, Hans W., de Bruyn, Marco
Publicado no Oncotarget (2016)