The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux

Oncogenic mutation of KRAS (Kirsten rat sarcoma viral oncogene homolog) in colorectal cancer (CRC) confers resistance to both chemotherapy and EGFR (epidermal growth factor receptor)-targeted therapy. We uncovered that KRAS mutant (KRAS(mut)) CRC is uniquely sensitive to treatment with recombinant L...

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Udgivet i:Autophagy
Main Authors: Wiersma, Valerie R, de Bruyn, Marco, Wei, Yunwei, van Ginkel, Robert J, Hirashima, Mitsuomi, Niki, Toshiro, Nishi, Nozomu, Zhou, Jin, Pouwels, Simon D, Samplonius, Douwe F, Nijman, Hans W, Eggleton, Paul, Helfrich, Wijnand, Bremer, Edwin
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Basic Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590647/
https://ncbi.nlm.nih.gov/pubmed/26086204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1063767
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