Loading...
Evaluation of structural effects on 5-HT(2A) receptor antagonism by aporphines: identification of a new aporphine with 5-HT(2A) antagonist activity
A set of aporphine analogs related to nantenine was evaluated for antagonist activity at 5-HT(2A) and α(1A) adrenergic receptors. With regards to 5-HT(2A) receptor antagonism, a C2 allyl group is detrimental to activity. The chiral center of nantenine is not important for 5-HT(2A) antagonist activit...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
|
| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4022183/ https://ncbi.nlm.nih.gov/pubmed/24630561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.02.066 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|