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Evaluation of structural effects on 5-HT(2A) receptor antagonism by aporphines: identification of a new aporphine with 5-HT(2A) antagonist activity
A set of aporphine analogs related to nantenine was evaluated for antagonist activity at 5-HT(2A) and α(1A) adrenergic receptors. With regards to 5-HT(2A) receptor antagonism, a C2 allyl group is detrimental to activity. The chiral center of nantenine is not important for 5-HT(2A) antagonist activit...
में बचाया:
| मुख्य लेखकों: | , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2014
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4022183/ https://ncbi.nlm.nih.gov/pubmed/24630561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.02.066 |
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