Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells.

High levels of the p53 protein are immunohistochemically detectable in a majority of human nonmelanoma skin cancers and UVB-induced murine skin tumors. These increased protein levels are often associated with mutations in the conserved domains of the p53 gene. To investigate the timing of the p53 al...

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Autors principals: Berg, R J, van Kranen, H J, Rebel, H G, de Vries, A, van Vloten, W A, Van Kreijl, C F, van der Leun, J C, de Gruijl, F R
Format: Artigo
Idioma:Inglês
Publicat: 1996
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC40221/
https://ncbi.nlm.nih.gov/pubmed/8552621
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