CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice

Mutations in the tumor suppressor p53 are detectable in over 50% of all human malignancies. Mutant p53 protein is incapable of transactivating its downstream target genes that are required for DNA repair and apoptosis. Chronic exposure to UVB induces p53 mutations and is carcinogenic in both murine...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tang, Xiuwei, Zhu, Yucui, Han, Lydia, Kim, Arianna L., Kopelovich, Levy, Bickers, David R., Athar, Mohammad
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2007
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2096455/
https://ncbi.nlm.nih.gov/pubmed/18060030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32481
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