Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells.

High levels of the p53 protein are immunohistochemically detectable in a majority of human nonmelanoma skin cancers and UVB-induced murine skin tumors. These increased protein levels are often associated with mutations in the conserved domains of the p53 gene. To investigate the timing of the p53 al...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Berg, R J, van Kranen, H J, Rebel, H G, de Vries, A, van Vloten, W A, Van Kreijl, C F, van der Leun, J C, de Gruijl, F R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40221/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8552621/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.1.274
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