Different TP53 mutants in p53 overexpressed epithelial ovarian carcinoma can be associated both with altered and unaltered glycolytic and apoptotic profiles

Abstract Background p53 is a tumor suppressor and key regulator of glycolysis in cancer cells, however highly mutated in tumors. In ovarian cancer, studies concerning p53 mutations focus on the DNA binding domain since the majority of hotspot mutations affects this region. Yet, mutations in other re...

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Váldodahkkit:	Stephanie Antoun, David Atallah, Roula Tahtouh, Nada Alaaeddine, Malak Moubarak, Abir Khaddage, Eliane Nasr Ayoub, George Chahine, George Hilal
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	BMC 2018-01-01
Ráidu:	Cancer Cell International
Fáttát:	Apoptosis Glucose metabolism Mutation p53 overexpression Ovarian cancer
Liŋkkat:	http://link.springer.com/article/10.1186/s12935-018-0514-2
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