Asparagine Depletion Potentiates the Cytotoxic Effect of Chemotherapy Against Brain Tumors

Targeting amino acid metabolism has therapeutic implications for aggressive brain tumors. Asparagine is an amino acid that is synthesized by normal cells. However, some cancer cells lack asparagine synthetase (ASNS), the key enzyme for asparagine synthesis. Asparaginase (ASNase) contributes to eradi...

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Библиографические подробности
Главные авторы: Panosyan, Eduard H., Wang, Yuntao, Xia, Peng, Lee, Wai-Nang Paul, Pak, Youngju, Laks, Dan R., Lin, Henry J., Moore, Theodore B., Cloughesy, Timothy F., Kornblum, Harley I., Lasky, Joseph L.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020976/
https://ncbi.nlm.nih.gov/pubmed/24505127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-13-0576
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