Asparagine Depletion Potentiates the Cytotoxic Effect of Chemotherapy Against Brain Tumors

Targeting amino acid metabolism has therapeutic implications for aggressive brain tumors. Asparagine is an amino acid that is synthesized by normal cells. However, some cancer cells lack asparagine synthetase (ASNS), the key enzyme for asparagine synthesis. Asparaginase (ASNase) contributes to eradi...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Panosyan, Eduard H., Wang, Yuntao, Xia, Peng, Lee, Wai-Nang Paul, Pak, Youngju, Laks, Dan R., Lin, Henry J., Moore, Theodore B., Cloughesy, Timothy F., Kornblum, Harley I., Lasky, Joseph L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020976/
https://ncbi.nlm.nih.gov/pubmed/24505127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-13-0576
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky