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Asparagine Depletion Potentiates the Cytotoxic Effect of Chemotherapy Against Brain Tumors
Targeting amino acid metabolism has therapeutic implications for aggressive brain tumors. Asparagine is an amino acid that is synthesized by normal cells. However, some cancer cells lack asparagine synthetase (ASNS), the key enzyme for asparagine synthesis. Asparaginase (ASNase) contributes to eradi...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4020976/ https://ncbi.nlm.nih.gov/pubmed/24505127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-13-0576 |
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