Asparagine Depletion Potentiates the Cytotoxic Effect of Chemotherapy Against Brain Tumors

Targeting amino acid metabolism has therapeutic implications for aggressive brain tumors. Asparagine is an amino acid that is synthesized by normal cells. However, some cancer cells lack asparagine synthetase (ASNS), the key enzyme for asparagine synthesis. Asparaginase (ASNase) contributes to eradi...

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Bibliografiske detaljer
Main Authors: Panosyan, Eduard H., Wang, Yuntao, Xia, Peng, Lee, Wai-Nang Paul, Pak, Youngju, Laks, Dan R., Lin, Henry J., Moore, Theodore B., Cloughesy, Timothy F., Kornblum, Harley I., Lasky, Joseph L.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020976/
https://ncbi.nlm.nih.gov/pubmed/24505127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-13-0576
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