Asparagine Depletion Potentiates the Cytotoxic Effect of Chemotherapy Against Brain Tumors

Targeting amino acid metabolism has therapeutic implications for aggressive brain tumors. Asparagine is an amino acid that is synthesized by normal cells. However, some cancer cells lack asparagine synthetase (ASNS), the key enzyme for asparagine synthesis. Asparaginase (ASNase) contributes to eradi...

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Detaylı Bibliyografya
Asıl Yazarlar: Panosyan, Eduard H., Wang, Yuntao, Xia, Peng, Lee, Wai-Nang Paul, Pak, Youngju, Laks, Dan R., Lin, Henry J., Moore, Theodore B., Cloughesy, Timothy F., Kornblum, Harley I., Lasky, Joseph L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020976/
https://ncbi.nlm.nih.gov/pubmed/24505127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-13-0576
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